Colonel Konstantin Humeniuk,
Chief Surgeon of Armed Forces
Ukraine
ProClot is a highly effective hemostatic remedy made from the natural substance chitosan, which is designed to stop various types of bleeding. It works independently of blood coagulation processes in the body, so it can be used in patients with hemophilia and other blood coagulation disorders, which is an important factor. Its action is associated with the formation of a powerful mucoadhesive barrier at the site of the wound upon contact with blood and other body fluids. The hemostatic effect is due to binding of positively charged elements of the medical product with negatively charged erythrocytes. When in contact with blood, it promotes the absorption of the liquid fraction of blood and forms a single gel-like mass, which helps to stop bleeding. Due to the large molecular weight of molecules that are saturated with hydroxyl groups, it forms hydrogen bonds with water (which makes up 90-95% of blood), which leads to the aggregation of formed blood elements and coagulation factors at the point of contact with the subsequent formation of a blood clot. We used this product in (n=119) cases of use of this product in wounded people with gunshot injuries of soft tissues at stabilization points, advanced surgical groups and mobile hospitals. A good hemostatic effect was noted for bleeding from soft tissue in the case of gunshot wounds and domestic injuries. There is currently no experience of stopping arterial bleeding from the great vessels of the limbs, given that the main temporary method of hemostasis is a tourniquet. Complications when using these products in the form of various pyrogenic reactions, toxic effects, secondary suppuration, allergic reactions were not noted. It can be used at the prehospital stage as a hemostatic remedy for bleeding of various genesis, taking into account the indicated indications and contraindications specified by the manufacturer. For the use of hemostatic remedy ProClot intra-abdominal bleeding at injuries liver, kidneys, spleen needs further scientific and practical research.